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KMID : 0377519890140010023
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Chung-Ang Journal of Medicine
1989 Volume.14 No. 1 p.23 ~ p.33
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A Karymetrical Study on the Erythropoietic Cells in the Liver of Human embryos and Fetuses
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Abstract
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This study was carried out for the quantitative analysis about the counts and the diameters of hepatic erythropoietic cell nuclei in 1 cases of human embryonic and fetal livers from 5 weeks to 40 weeks of gestation under a light microscope. The purposes of this study were to obtain informations`about the initiation time of hepatic hemopoiesis, and the stages of activity and the distribution of nuclear diameters of hepatic erythropoietic cells in human embryos and fetuses.
The results obtained were as follows.
1. Hepatic erythropoietis began in 6 weeks of gestation; and many proerythroblasts and undifferentiated cells more than 7m in nuclear diameter appeared in primitive hepatic cords. Megakaryocytes appeared around central veins in the 7-week embryo and a few granulocytes were seen in hepatic cords and in mesenchymal tissue around large vessels in the 8-week embryo.
2. Hepatic erythropoietic activity was rapidly increasing at the embryonic period from 6 weeks to 10 weeks to gestation, and many erythroblasts were observed in primitive hepatic cords from 7 weeks to 8 weeks of gestation.
3. Hepatic erythropoietic activity was maintained at the highest level from 10 weeks to 21 weeks of gestation, and various hepatic erythropoietic cells showed between 3 and 8m in nuclear diameters.
4. The gestation period from 22 weeks to 40 weeks of gestation was the last period in hepatic erythropoietis and in that period erythropoietic activity began to decrease definitely. With age, immature hepatic erythropoietic cells became to disappear and only mature erythroblasts were seen. Erythropoietic activity decreased rapidly from 33 week to 40 weeks of gestation.
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